Long noncoding RNA CASC7 inhibits the proliferation and migration of papillary thyroid cancer cells by inhibiting miR-34a-5p

Abstract Long noncoding RNAs (lncRNAs) play an essential role in the progression of papillary thyroid cancer (PTC). However, expression and function lncRNA susceptibility candidate 7 (CASC7) PTC remain unknown. The purpose this study was to investigate molecular mechanism CASC7 regulating cell behavior. CASC7, miR-34a-5p, tumor protein P73 (TP73) determined by qRT-PCR western blot. Cell proliferation examined MTT assay. apoptosis assessed flow cytometry following Annexin V PI staining. migration Transwell interaction between miR-34a-5p or TP73 luciferase reporter were significantly lower, whereas higher tissues than adjacent normal tissues. Furthermore, overexpression inhibited migration, facilitated human lines (K1 TPC-1). Mechanistically, acted as a sponge upregulate expression. Moreover, mimic transfection could abate CASC7-regulated proliferation, apoptosis. Collectively, cells sponging